Catharanthus roseus is well known for its pharmacological significance. The present study aims to determine the antifungal activity of Catharanthus roseus against various clinically significant fungal strains (Candida albicans, Aspergillus fumigatus, Aspergillus niger, Fusarium moniliforme). Assessment of antifungal activity of Catharanthus roseus was done by paper disc diffusion method. In thi...

The Catharanthus roseus L. plant leaf extracts were prepared by using solvents such as acetone, ethanol, and chloroform and tested against pathogenic microorganisms to determine their antimicrobial potential. Catharanthus roseus leaf extracts showed maximum antibacterial activity against all the pathogenic microorganisms. Among the solvents tested, ethanol showed maximum antibacterial activity ...

Herbal medicine industry in Indonesia was shaken when Indonesian National Agency of Drugs and Food control prohibits the development of herbal medicines made from Catharanthus roseus. The reason given is that Catharanthus roseus contains alkaloids causing bone marrow depression. The purpose of this article to explore the effects of both preclinical and clinical pharmacological of Catharanthus r...

Catharanthus roseus (= Vinca rosea), Adenine Phosphori­ bosyltransferase, Subcellular D istribution, Mitochondria, Purine Salvage Subcellular localization of adenine phosphoribosyltrans­ ferase was examined in Catharanthus roseus cells. At least 13% of the activity was observed in the particulate fraction with the rest observed in the cytosol. Both differential and Percoll density gradient cent...

The leaves extract of Catharanthus roseus was investigated for hypotensive and hypolipidemic effects in adrenaline-induced hypertensive rats (AIHR) and compared with those of Atenolol in a crossover design. The pharmacologically Active components responsible for hypotensive activities were isolated from plant using bioassay guided purification approach and the structure of the compounds was pro...

Induced mutagenesis is best approach for creation of genetic variability but most of interest is paid towards crop plants with only a few exceptions. But even widely used medicinal plants could receive a little attention in this direction. Catharanthus roseus is an important plant medicinal plant yielding antihypertensive alkaloid ajmalcine and anticancerous alkaloid vincristine and vinblastine...

Catharanthus roseus (L.) which is an important medicinal plant of the family Apocynaceae is used to treat many of the fatal diseases contains a virtual cornucopia of useful alkaloids, used in diabetes, blood pressure, asthma, constipation, and cancer and menetrual problem. There are about two common cultivars of C. roseus which is named on the basis of their flower colour that is the pink flowe...

Catharanthus roseus is a medicinal herb found in many tropical and subtropical regions around the world. This plant produces a diverse array of secondary metabolites that are pharmaceutically important like vinblastine and vincristine used as chemotherapeutic agents in the treatment of several types of cancers. Low yield of these vinca alkaloids from the plant in vivo and the challenges to meet...

Diabetes becomes a real problem of public health in developing countries, where its prevalence is increasing steadily. Diabetes mellitus can be found in almost every population in the world. Since the Ayurvedic practice started in India, plants are being used in the cure of diseases. Although the Catharanthus roseus have been used for their alleged health benefits and avail their hypoglycemic e...

The manuscript published by Microb Biotechnol, volume 10, highlights the relevance of the fungus Nigrospora sphaerica, an endophyte isolated from Catharanthus roseus, as an alternative source to obtain vinblastine, a compound used in chemotherapy schemes to treat several types of cancer. Authors showed that purification of vinblastine from extracts of the fungus has higher activity and yield in...